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ZOVIRAX (Acyclovir) is a trademark for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX (Acyclovir) capsules, tablets, and the suspension is the composition for oral administration. Each capsule in ZOVIRAX (Acyclovir) contains 200 mg acyclovir and inactive ingredients of bread starch, lactose, magnesium stearate and sodium lauryl sulfate. In capsule shell consists of gelatin, FD and C Blue No. 2, and titanium dioxide. May contain one or more parabens. Printed with edible black ink.
Each 800-mg tablet of ZOVIRAX (Acyclovir) contains 800 mg per acyclovir and inactive ingredients and FD C Blue No. 2, magnesium stearate, microcrystalline cellulose, povidone, and sodium starch glycolate.
Each 400-mg tablet of ZOVIRAX (Acyclovir) contains 400 mg per acyclovir and inactive ingredients of magnesium stearate, microcrystalline cellulose, povidone, and sodium starch glycolate.
Every teaspoonful (5 ml) of ZOVIRAX (Acyclovir) Suspension contains 200 mg acyclovir and inactive ingredients methylparaben 0,1% and propylparaben 0,02% (added as a preservative), sodium carboxymethylcellulose, taste, glycerin, sorbitol and microcrystalline cellulose.
Acyclovir is a white, crystalline powder with a molecular formula C8H11N5O3, and molecular weight of 225. The maximum solubility in water at 37 ° C and 2,5 mg / ml. In pka x acyclovir are 2,27 and 9,25.
The chemical name of acyclovir 2-amino-1, 9-dihydro-9-[(2-hydroxyethoxy) methyl] - 6H - purin-6-one;
VIROLOGY
Mechanism Antiviral decision: Acyclovir is a synthetic purine nucleoside analogs in vitro and in living inhibitory activity against herpes virus simply type 1 (HSV-1), 2 (HSV-2), and varicella-opoyasyvayuschy depriving virus (VZV).
In the inhibitory activity acyclovir is highly selective, because of its affinity for the enzyme thymidine kinase (TK) encoded in HSV and VZV. This viral enzyme converts acyclovir in acyclovir monophosphate year nucleotide analogue. In further converted to monophosphate diphosphate on cellular guanylate kinase and ATF in a number of cellular enzymes. In vitro, acyclovir ATF stops herpes viral DNA replication. This is done three ways: 1) competitive inhibition of viral DNA polymerase, 2) the inclusion in the growing chain and cessation of viral DNA, and 3) inactivation of viral DNA polymerase. The more antiviral activity against HSV acyclovir compared with VZV explains its more efficient phosphorylation of viral TK.
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